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FORMULATION AND EVALUATION OF EXPANDABLE GASTRORETENTIVE TABLET.
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Anilkumar Shinde and Harinath More
ISBN: 9786200276544
Год издания: 1905
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 56
Издательство: LAP LAMBERT Academic Publishing
Цена: 25002 тг
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Аннотация: The present study was to maintain the levels of diltiazem hydrochloride within a desired range, reduction in its dosing frequency and increase bioavailability. The tablets were formulated by using of 32 factorial design, the effect of independent variables X1 (concentration of hydroxy propyl methylcellulose K100) and X2 (concentration of sodium carboxymethylcellulose) on swelling index and drug release was studied. Tablets were prepared by direct compression method using 13 mm punch on rotary tablet machine. Physical properties of compressed tablets such as hardness, friability, content uniformity, swelling index were determined. The swelling index of optimized batch varied between 114.21 and 220.41 %. The percentage drug release of optimized batch was 15.60% at 1 h and 71.97% at 12 h. From the drug release kinetic study, Peppas model was found to be best fit. Infrared spectrum showed that there was no interaction between drug and polymers in the formulation. The sustained drug release pattern was successfully achieved through the formulation of expandable gastroretentive tablets.
Ключевые слова: Antihypertensive drug, diltiazem hydrochloride, expandable tablet, Factorial Design, Gastroretentive, swelling study