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Solid dispersion: A method to enhance the solubility of drugs. Solubility improvement technique
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Bhaskar Daravath
ISBN: 9786204750682
Год издания: 1905
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 200
Издательство: LAP LAMBERT Academic Publishing
Цена: 47541 тг
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Аннотация: The book is intended for UG, PG, and research scholars as a research guide on the method used to enhance the solubility, dissolution, and bioavailability of BSC class II drugs. BCS class II drugs generally have low oral bioavailability due to poor water solubility. The solid dispersions were prepared by using various hydrophilic carriers in different ratios. The molecular dispersion of the drug in the carrier may change the solid-state property of the drug from crystalline to amorphous form. The improvement in drug dissolution can be achieved by reducing particle size and increasing surface area, improved wetting of the particles, and particles with high porosity. The solid dispersion method was suitable to improve the solubility, dissolution, and bioavailability of BCS class II drugs.
Ключевые слова: BCS class II drugs, solubility, Hydrophilic carriers, Dissolution, Pharmacokinetics
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