The Major Approaches for Boosting Aqueous Solubility, Dissolution Rate, and Oral Bioavailability. Development of Solid Dispersion of Insoluble Pharmaceuticals Based on Hydrophilic Carriers and Hydrotropic Blends

      Аннотация: Poorly water-soluble drugs have emerged as the central challenging aspect that should be probed by scientists during drug development. These obstacles change the way of development of medicines from formulation to overcoming such types of problems. Several methods have been used to treat these limitations. Still, the solid dispersion method is getting the most substantial attention because it can improve the solubility, dissolution rate, and bioavailability of such kinds of drugs effectively. That's why it was recognized as the most effective method for that purpose during drug development. Antihyperlipidemic agent atorvastatin calcium (ATV) faced a problem after oral administration due to low water solubility characteristics. Boosting the solubility and oral bioavailability of such kinds of drugs are the major obstacles that formulation scientists faced. This Study’s aim was to enhance the solubility and dissolution rate of ATV by the formation of solid dispersion-based hydrotropic blends. Solid dispersion-based hydrotropic blends can result in the production of the dosage forms of practically insoluble drugs with an optimum enhancement ratio in their solubility.

Ключевые слова: Water-Solubility, solid dispersion, Hydrotropic agent