Titanium Dioxide. Quercetin Combinational Drug’s Role in Skin Cancer

      Аннотация: This book describes the role of titanium dioxide nanotubes conjugated with quercetin in skin cancer and inflammation. TNT-Quercetin are human safe, cost effective and stable chemical with numerous biomedical applications. The authors of this book developed a novel drug combinational molecule by conjugating TNT with quercetin. The authors found the enhanced anti-cancer activity of TNT–Qu by inducing apoptosis and cell cycle arrest at the G2/M phase in B16F10 cells. Furthermore, TNT–Qu treatment up-regulated cleaved caspase-3 expression in B16F10 cells. More importantly, the in-vivo data demonstrated that TNT–Qu treatment inhibited the growth and metastasis of skin tumors significantly by down-regulating the pSTAT3 expression and restoring γδ T cell population when compared to TNT or quercetin alone treatment. Taken together, the in-vitro and in-vivo data strongly suggest that TNT–Qu could be a novel combinational therapeutic agent for the treatment of skin cancer.

Ключевые слова: Titanium dioxide nanotubes, quercetin, TNT-Quercetin, skin cancer, Nanomedicine