Starch Malonate - A New Modified Starch Based Superdisintegrant.

      Аннотация: Dosage forms are designed in such a way that they can benefit a wide range of patients groups with ease of administration, safety and efficacy. Fast Dissolving Tablets are the most preferred dosage forms nowadays for enhanced quick action, less adverse effects, doctor's choice for all age patients, especially for pediatric, geriatric, and psychotic patients. Superdisintegrants achieve quick disintegration of tablets. Superdisintegrants cause the breakdown of tablets by different mechanisms like swelling, wicking, chemical reaction, repulsive force in between particles, heat due to wetting, enzymatic reactions, and recovery after deformation. But 90% of the superdisintegrants are worked by a mechanism named swelling and wicking. Starch Malonate is a superdisintegrant helps in the faster breakdown of tablets. It helps in the preparation of Fast Dissolving Tablets of poorly soluble drugs and results in faster DT, immediate action and enhanced drug release and bioavailability.

Ключевые слова: Fast Dissolving, Paediatrics, Geriatric, Superdisintegrant, Starch Malonate