FILM FORMATION. “FORMULATION AND EVALUATION CLOTRIMAZOLEDERMAL FILM

      Аннотация: Global incidence of superficial fungal infections caused by dermatophytes is high and affects around 40 million people. It is the fourth most common cause of infection. Clotrimazole, a broad spectrum imidazole antifungal agent is widely used to treat fungal infections. Conventional topical formulations of clotrimazole are intended to treat infections by effective penetration of drugs into the stratum corneum. However, conventional have drawbacks such as poor dermal bioavailability, poor penetration, and variable drug levels limit the efficiency. The present study aims to formulation and evaluation of Clotrimazole dermal film. Clotrimazole loaded film were prepared using HPMC and HEC by solvent casting method and evaluated for drug content, % flatness, folding endurance, drug. Skin diffusion studies were performed using to determine the amount of clotrimazole accumulated in different layers of the skin. Results showed that the optimized formulation had good thickness higher drug content and slow diffusion with time. No permeation was observed through the skin up to 12 h following the permeation studies.

Ключевые слова: diffusion, film, Clotrimazole