Nano Emulgel: An Innovative Drug Delivery in Remission of Rosacea. An Innovative Metronidazole Loaded Carrier for Topical Delivery in Remission of Rosacea

      Аннотация: Rosacea is a widely prevalent skin disorder among 30 to 50 years age men and women. Numerous discoveries are in pipeline to instigate the etiology of rosacea since it has various sheathes. Though numerous topical conventional drug delivery in practice to overcome the disorder, usage of broad-spectrum sunscreen and engage in sun avoidance behavior are crucial for managing rosacea in the lifestyle area. In this context, our research study proposed to a potential metronidazole incorporated nanoemulgel using carbopol 940 with different concentration as a gelling agent. The observed results from invitro diffusion shows that metronidazole nanoemulgel could be beneficial to treat rosacea with a better retention time as compared to market gel conventional formulation. However, further preclinical and clinical studies are required to access the bioavailability of the drug.

Ключевые слова: metronidazole, Nanoemulgel, Carbopol 940, Skin irritation, in-vitro drug permeation.