Immunohistochemical Expression of Paxillin in Oral lesions. Paxillin in oral premalignant and malignant lesions

      Аннотация: Cell adhesion molecules are essential to maintain the integrity of stratified squamous epithelium. In normal control, keratinocytes are attached to each other and to the underlying basement membrane. Cell adhesion, on the other hand, must be dynamic to aid the mobility and turnover of cells. Keratinocytes modify their cell-cell and cell-ECM interactions by feature of altered expression and function of CAMs, in dynamic situations. It is now well established that paxillin is a focal adhesion associated adaptor protein that recruits signaling molecules into a complex. The functions of paxillin appear to include the regulation of cell spreading and cell motility, and these functions are presumably elicited by coordinating signaling events by paxillin associated proteins.Cell adhesion molecules are essential to maintain the integrity of stratified squamous epithelium. In normal control, keratinocytes are attached to each other and to the underlying basement membrane. Cell adhesion, on the other hand, must be dynamic to aid the mobility and turnover of cells.

Ключевые слова: immunohistochemistry, Paxillin, Oral malignancy