Ocular dispersions for dry eye syndrome management. Single or dual drug-loaded colloidal dispersions to manage moderate to severe dry eye syndrome

      Аннотация: Highlighting the use of colloidal dispersions as eyedrop formulations containing single or dual drugs has garnered significant interest. This book covers the development of formulas, preclinical safety evaluation, and animal studies for single drug-loaded emulsion eyedrops. It explains how to convert liquid-retentive eyedrops into solid-dry powder for reconstitution, prolonging colloidal stability. Applying a polymer coat to dispersed oil droplets forms nanocapsules, extending drug release in nanocapsule-based eyedrops. The book elucidates two-compartment formation in nanocapsules and emulsion eyedrops, accommodating different drugs without interactions. Dual drug-loaded colloidal dispersions manage moderate to severe dry eye syndrome, achieving combination therapy and inflammation reduction.

Ключевые слова: colloidal dispersions, cyclosporin A, Dry Eye Syndrome, Etodolac, SYNERGISM