Biophysical & Biochemical Characterization of Hepatocellular Carcinoma. Advanced Biophysical and Biochemical Techniques Characterized Hepatocellular Carcinoma

      Аннотация: Hepatocellular carcinoma (HCC) is an extremely prevalent malignancy that is the fourth world ‎wide. It is an important contributor to the mortality of those with chronic liver diseases in both ‎developing and developed countries. Early detection of cancer offers the best chance for cure; this is ‎why screening for HCC is recommended on regular basis. Screening may involve blood tests to ‎detect the level of tumor markers in serum and radiological tests including CT, MRI and ultrasound ‎imaging. In the current work, the detection possibility of the structural changes in serum proteins ‎accompanying cirrhosis and HCC is investigated using Low-Angle X-ray Scattering (LAXS) ‎technique. Also, the serum levels of some biochemical factors which are probably related to ‎cirrhosis and HCC are measured. The LAXS results showed that there are significant differences in ‎the LAXS profiles of cirrhosis and HCC lyophilized serum samples compared to normal. The ‎changes in shape, total counts and position of the first scattering peak at 4.8 degrees, which was previously ‎reported to be sensitive to the structural changes in protein, showed the most characteristic deviations ‎from normal serum.‎

Ключевые слова: Medical Biophysics, Hepatocellular carcinoma, Low angle x-ray scattering, Detection of HCC