Gastroretentive Superporous Hydrogel Tablets-Esomeprazole. Preparation and Evaluation

      Аннотация: All the formulations were prepared by direct compression method. The prepared tablets of all the formulations were evaluated for physical characters, assay, in‐vitro drug release, swelling index, hardness and friability. The main aim was to optimize the formulation for 1-12 hours in‐vitro release. Optimized formulation F9 containing chitosan and xanthan gum in 1:1 ratio shows better drug release up to 12hours was consider as the best product with respect to in-vitro drug release for 12 hours release action and improved site‐specific action. The results showed that the drug release rate was decreased as the viscosity of the polymer was increased. The drug release kinetics was performed for the optimized formulation and it shows zero order with super case II transport drug release.

Ключевые слова: Esomeprazole, superporous, hydrogel, evaluation