Topical Pluronic Lecithin Organogel for Pain Management. Formulation and evaluation of novel controlled release topical pluronic lecithin organogel of mefenamic acid

      Аннотация: Pluronic lecithin based organogels were formulated as topical carrier for controlled delivery of mefenamic acid, an analgesic and anti-inflammatory drug practically insoluble in water. The organogels were prepared by method employing lecithin and pluronic as oil phase and aqueous phase respectively. Isopropyl myristate (IPM) was used as organic solvent for lecithin, whereas gelation was achieved by slowly addition of aqueous phase (Pluronic). Ten formulations were prepared using varying concentration of lecithin and pluronic. Increase in the amount of lecithin resulted in organogels with higher viscosity and lower spreadability and same pattern was followed when pluronic with varying concentrations was used. Organogels with higher viscosity were found to be more stable and controlling the release rate. All formulations were found to have pH value within the range of 5.56-5.80 i.e. within skin pH range. So none of the formulations were found irritant to the skin. In vitro release of mefenamic acid from organogels showed that organogels containing 2% lecithin (F2) gave highest release in 8 hours.

Ключевые слова: In vitro anti-inflammatory activity, Mefenamic acid, in vitro release, Pluronic lecithin organogels