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Indomethacin β-CD Loaded Mouth Dissolving Film. Formulation and Characterization
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Srinivasa Rao Yarguntla
ISBN: 9786206791928
Год издания: 1905
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 108
Издательство: LAP LAMBERT Academic Publishing
Цена: 35077 тг
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Аннотация: The main aim of the present investigation was to formulate and characterize a β-cyclodextrin loaded indomethacin mouth dissolving film to bypass the first pass metabolism Indomethacin is a non-steroidal anti-inflammatory agent (NSAIA) with anti-inflammatory, analgesic, antipyretic activity. Its pharmacological effect is thought to be mediated through inhibition of the enzyme cyclooxygenase (COX), the enzyme responsible for catalyses the rate-limiting step in prostaglandin synthesis via the arachidonic acid pathway. indomethacin- β cyclodextrin loaded mouth dissolving film prepared by solvent evaporation technique with various hydrophilic polymers like hydroxyl Propyl methyl cellulose (HPMC) 15cps, HPMC K100M, SLS(sodium lauryl sulphate), and PEG 400 & PEG 600.The formulated mouth dissolving film were evaluated for their physiochemical parameters like weight variation, thickness, folding endurance, drug content, moisture content and moisture absorption. In vitro drug release was carried out by dissolution apparatus. All these mouth dissolving film were shows >70% of drug released within half an hour and obeyed first order release kinetics.
Ключевые слова: Indomethacin, beta-cyclodextrin, Mouth dissolving film, formulation, evaluation