Phytochemical study and cancer chemopreventive effect of Caryota sp.. Comparative bioactivity guided study for the cancer chemopreventive effect of Caryota mitis Lour. and Caryota urens L.

      Аннотация: The book presents the first metabolome profiling of Caryota mitis Lour. and Caryota urens L. (F. Arecaceae) in a comparative manner. HR-UPLC/PDA/ESI-MS analysis of their leaf and fruit various extracts resulted in identification of 142 metabolites including 104 first time reported in genus Caryota, 7 in family Arecaceae and a new phenolic acid. GC/MS analysis of their petroleum ether leaf extracts resulted in identification a total of 40 unsaponifiable compounds and 29 fatty acid methyl esters. The study reveals the potential role of both crude and successive leaf extracts in cancer chemoprevention via NQO1 enzyme induction traced using DCPIP assay where the crude leaf extract of C. mitis and C. urens induced the cytoprotective NQO1 enzyme by 4.5-5 folds the vehicle control. Phytochemical investigation of the active extracts: C. urens petroleum ether and C. mitis ethanolic leaf extracts led to isolation of 13 compounds identified by different spectroscopic techniques that included 3 new compounds and 4 reported for the first time in genus Caryota

Ключевые слова: Caryota Sp., NQO1 inducers, Profiling, Docking, western blot, active compounds