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 | Отрасли знаний: Медицина Martin Pejchinovski The role of urinary peptide markers in severe renal diseases. 2017 г., 52 стр., мягкий переплет Today’s goal of every interdisciplinary medical center is to provide well-timed prevention of therapeutic intervention and proper management of disease patients in daily clinical practice. This book "The role of urinary peptide markers in severe renal diseases" gives interesting workflow, high-throughput screening of the urine proteome by... | 25828 тг  |
 | Отрасли знаний: Медицина Mohammed Ayesh Al-Madol Inflammation and Pain. Gene expression and immunohistochemical localization of distinct modulators of inflammation and pain 2017 г., 68 стр., мягкий переплет Acute as well as chronic pain leads to suffering and impaired quality of life. This project examined three different ways of pain modulation. In the first study, distinct profiles of pro-versus anti-inflammatory mediators were characterized for patients with various joint diseases. In the second study mineralocorticoid receptors (MR) as potential... | 23493 тг |
 | Отрасли знаний: Медицина Linda Maria Seefeld Health-Seeking Behaviour of Buruli ulcer affected People in Ghana. A Mixed Methods Study conducted in a rural Sub District of the Eastern Region, Ghana 2017 г., 296 стр., мягкий переплет Buruli ulcer (BU) is one of the least studied neglected tropical diseases. It is a chronic necrotising skin and soft tissue disease that may also affect the bone. The majority of BU affected people seek medical care only at an advanced stage of the disease, but research into reasons for this behaviour and local disease perceptions is still... | 58211 тг |
 | Отрасли знаний: Медицина Temaj Gazmend Molecular environment and expression strategy of therapeutic target. 2017 г., 128 стр., мягкий переплет In molecular medicine, for many years, manipulation of disease genes for therapeutic reason has been a major subject. The focus has been on manipulation of gene expression at the level of DNA to change mRNA espression. For reasons of therapeutic feasibility, often expression of mRNA is increased or decreased via viral vectors. However, these... | 35304 тг |
 | Отрасли знаний: Медицина Kushtrim Kryeziu Anticancer activity and targeted delivery of metal-based drugs. 2017 г., 284 стр., мягкий переплет In this thesis, promising representatives of approved and novel metal-based drugs containing arsenic, ruthenium and platinum were analyzed for their anticancer activity. Strategies such as drug combinations, polymeric nanoformulations, and drug structure modifications were employed to increase their anticancer activity, overcome drug resistance,... | 57785 тг |
 | Отрасли знаний: Медицина -> Фармакология и фармацевтика Herve Sergi Akone Secondary Metabolites from Fungi. Strategies of Activation of Silent Biosynthetic Pathways, Structure Elucidation and Biactivity 2017 г., 152 стр., мягкий переплет Since the discovery of penicillin, fungi stand as an inexhaustible source of novel chemotypes and pharmacophores. A particular interest is given to fungi that are referred to endophytic fungi which are fungi inhabiting internal tissues of plant without causing any visible symptoms of disease. In the past two decades, endophytic fungi have been... | 40029 тг |
 | Отрасли знаний: Медицина Yuehua Mai Mutational Analysis in Patients with Uveal Melanomas. Evidence for Clonal Evolution 2016 г., 92 стр., мягкий переплет There is no standard treatment for the advanced and metastatic uveal melanoma so far, genotypic characterization of uveal melanoma might identify patients who could benefit from a drug-target based approach. In our study, mutations in genes GNAQ and GNA11, BRAF, NRAS, and KIT in primary and matched metastatic uveal melanoma specimens were... | 34025 тг |
 | Отрасли знаний: Медицина -> Фармакология и фармацевтика Mai Anh Nguyen Pharmacokinetic Food Supplement-Drug Interaction. The Influence of Flavonoids on Drug Transport and Metabolism in Humans 2016 г., 208 стр., мягкий переплет Nutraceuticals are food supplements containing the bioactive components in drug formats with doses that exceed the amounts available from the diet. The concomitant intake of nutraceuticals and drugs can produce hazardous interaction, affecting the efficacy and safety of drug therapy. The present work provides a detailed introduction to... | 47389 тг |
 | Отрасли знаний: Медицина Naim Kittana Regulation of Connective Tissue Growth Factor in Cardiac Fibroblasts. 2016 г., 148 стр., мягкий переплет The connective tissue growth factor (CTGF), also known as CCN2, is highly expressed during embryonic development and later up regulated in almost all fibrotic tissues including the fibrotic heart. With this respect, it has been demonstrated that myofibroblasts but also other cardiac cells are substantial sources of CTGF. This factor is known to... | 39887 тг |
 | Отрасли знаний: Медицина Hongkai Shang Effects of dexamethasone on glucocorticoid receptors in ovine placenta. 2016 г., 108 стр., мягкий переплет this study for the first time demonstrated the presence of three different GR?-BNC-subtypes in sheep placenta. The number of GR? BNCs was regulated by early DEX treatment and this effect was long lasting and sex-, subtype-, placentome-subtype- and level-dependent. Early in pregnancy, DEX may reduce the function of BNCs via increased proportion of... | 34594 тг |
 | Отрасли знаний: Медицина Tatiana Nikitina Influence of iodinated contrast media on vascular function. 2016 г., 52 стр., мягкий переплет My work is directed to vascular physiology. During my doctorate I studied function of arterial vessels of the brain and the kidney. I learned techniques for their investigation including dissection, mounting, performance of experiments, data analysis, and data interpretation. I isolated vessels of various sizes from different vascular beds of rats... | 25828 тг |
 | Отрасли знаний: Медицина Kalliope Nina Diakopoulos Role of autophagy in pancreatic disease. 2015 г., 128 стр., мягкий переплет Autophagy describes a homeostatic mechanism, crucial for the regulation of cell metabolism and survival. In order to decipher the role of autophagy in exocrine pancreatic physiology, mice with pancreas specific deletion of the central autophagy regulator Atg5 were characterized in detail. Mice were treated with specific diets to study the effect... | 32883 тг |
 | Отрасли знаний: Медицина Xiang Zhang Female sex and ER-alpha modulate cardiac ischaemic remodeling. Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice 2015 г., 92 стр., мягкий переплет In this study, we present novel insights into mechanisms that account for the ER?-dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a cardiomyocyte-specific ER?-overexpression (ER?-OE), we first demonstrated that this was associated with an increase of LVM... | 34025 тг |
 | Отрасли знаний: Медицина Cornelia Schuh Oxidative Tissue Injury in Experimental Models of Multiple Sclerosis. 2015 г., 180 стр., мягкий переплет Multiple sclerosis (MS) is a chronic disease of the central nervous system. A number of different animal models of MS contributed to a better understanding of MS pathology. Additionally, experimental models enabled the development of immune-modulatory therapies for MS patients. In recent years, growing evidence for a major role of oxidative injury... | 39087 тг |
 | Отрасли знаний: Медицина Aaruni Saxena Insight into Aspirin and NSAIDs interactions. 2014 г., 80 стр., мягкий переплет NSAID and Aspirin interactions have been well reported during the last decade. However, the reason behind These interaction are still unknown. This book presents the possible causes of both interacting and non- interacting NSAIDs with the cardioprotective anti-thrombotic effect of Aspirin. In the modern era of medicine, both NSAIDs and Aspirin are... | 26823 тг |
 | Отрасли знаний: Медицина -> Фармакология и фармацевтика Noha Swilam Chemistry and Biology of Phenolics Isolated from Myricaria Germanica. 2014 г., 212 стр., мягкий переплет Tamgermanitin, a unique N-trans-Isoferuloyltyramine, together with the hitherto unknown polyphenolics, 2,4-di-O-galloyl-(?/?)-glucopyranose and kaempferide 3,7-disulphate have been isolated from the leaf aqueous ethanol extract of the false tamarisk, Myricaria germanica DESV. In addition, 18 known phenolics were also separated and characterized.... | 52807 тг |
 | Отрасли знаний: Медицина Monika Hackl Completeness Estimation of Austrian Cancer Incidence Data. 2014 г., 96 стр., мягкий переплет Regional comparison of cancer incidence rates is one of the most important and most challenging tasks in cancer epidemiology. If the degree of completeness of case ascertainment differs between the regions compared – which it usually does – no meaningful comparison is possible. Therefore, completeness has to be assessed and differences... | 28359 тг |
 | Отрасли знаний: Медицина -> Стоматология Shweta Sedani and Deepak Ruparel Microscopes in Endodontics. 2014 г., 108 стр., мягкий переплет Like other sciences, dentistry too is dynamic. It requires an original approach from an author for a major thrust in research. The one who inclines the readers to experimentation contributes his/her real worth to this noble profession. I admit in all humility that I have tried a bit in this direction. This book named "Microscopes in... | 32173 тг |
 | Отрасли знаний: Медицина Katja Franke BrainAGE. A novel machine learning approach for identifying abnormal age-related brain changes 2014 г., 168 стр., мягкий переплет Based on the widespread but well-ordered brain tissue loss that occurs with healthy aging into senescence, this work presents a novel magnetic resonance imaging (MRI)-based biomarker, which identifies normal and abnormal aging-related brain atrophy. The novel BrainAGE approach is based on a database of structural MRI data, aggregating the complex,... | 38661 тг |
 | Отрасли знаний: Медицина Silvia Elizabeth Ferrari Detection of anti-ADAMTS13 antibodies in patients with TTP. Characterization of the immune response against ADAMTS13 in patients with thrombotic thrombocytopenic purpura 2014 г., 104 стр., мягкий переплет Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease caused by a deficiency in ADAMTS13 which in the acquired form is provoked by autoantibodies against this protease. The main objective of this work was to study the pathophysiologic and prognostic value of anti-ADAMTS13 antibodies in patients with acquired TTP. The surveyed... | 34452 тг |
 | Отрасли знаний: Медицина Rob Labruy?re New outcome measures for subjects with incomplete spinal cord injury. Response time and adaptive walking 2014 г., 220 стр., мягкий переплет This book presents two new outcome measures for patients with incomplete spinal cord injury. The Figure of Eight Test is a walking test that incorporates curve-walking and challenging situations like obstacles or cognitive distraction. It is a valid assessment tool in healthy subjects as well as subjects with incomplete spinal cord injury, and it... | 48251 тг |
 | Отрасли знаний: Медицина Daniela Much Nutritional fatty acids during pregnancy & lactation. Do they play a role as a prevention strategy against childhood overweight in early life? 2014 г., 184 стр., мягкий переплет In recent years, increasing attention has been given to the effects of maternal supplementation with n-3 long-chain polyunsaturated fatty acids (LCPUFA) during pregnancy on pregnancy outcome and later child development. A relatively new upcoming issue in the context of maternal supplementation with n-3 LCPUFA during pregnancy is the role of n-3... | 39229 тг |
 | Отрасли знаний: Медицина -> Стоматология Bernhard Pommer Minimally Invasive Sinus Membrane Elevation. For Maxillary Bone Augmentation 2013 г., 160 стр., мягкий переплет Transcrestal elevation of the maxillary sinus membrane provides a minimally invasive treatment option to augment bone volume for dental implant placement in the edentulous posterior maxilla. The present thesis details on surgical as well as preoperative planning procedures of an innovative technique to elevate the sinus membrane using gel... | 41281 тг |
 | Отрасли знаний: Медицина Sarah Schwitalla NF?B signaling in different stages of intestinal carcinogenesis. 2013 г., 196 стр., мягкий переплет Colorectal cancer remains one of the major health concerns as it is the 2nd most common cause of cancer deaths in developed countries including more than 1 million new diagnosed cases each year. Risk factors are mostly conditioned by environmental influences but also by chronic inflammation. The transcription factor NF-?B is known as the key... | 42560 тг |
 | Отрасли знаний: Медицина -> Клиническая медицина Зумрад Эргашева Метаболизм катехоламинов и процессы ПОЛ при артериальной гипертензии. Монография 2019 г., 116 стр., мягкий переплет Гипертоническая болезнь (ГБ) представляет собой самостоятельное заболевание, главным признаком которого является повышенное артериальное давление, сопровождающееся вовлечением в... | 32457 тг |
