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Omega-3 fatty acids attenuate DNA damage in experimental diabetes.
В наличии
| Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Jihan Hussein,Mamdouh Taha and Sahar Mohamed
ISBN: 9783659664762
Год издания: 2014
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 148
Издательство: LAP LAMBERT Academic Publishing
Цена: 36982 тг
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Аннотация: Supplementation of omega-3 fatty acids is very effective in reducing oxidative stress through the improvement of antioxidant enzymes activities . Fish and flaxseed oils are nutritional supplements have a high concentration of omega-3 fatty acids.Flax seed oil is rich in alpha linolenic acid (ALA) while fish oil is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this study we aimed to compare the effects of flaxseed and fish oils in reducing oxidative stress especially in attenuating DNA damage through the evaluation of urinary 8-hydroxyguanosine (8-OHdG) in experimental diabetes. The main finding in our study was the reduction of urinary isoprostanes and 8-OHdH , in addition to the reduction of insulin resistance during diabetes. In conclusion, flaxseed and fish oils administration has a potential effect on decreasing insulin resistance in diabetic rats through the scavenging of free radicals and increasing superoxide dismutase . This study also concluded that ,fish oil was more effective than flaxseed oil.
Ключевые слова: Diabetes mellitus, DNA, fatty acids, phospholipids
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