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Natural Killer Cells Phenotype and Hepatitis C Virus Infection.
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| Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Somaya El-Deeb,Hosni Salama and Asmaa Elsayed
ISBN: 9783659788031
Год издания: 2015
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 136
Издательство: LAP LAMBERT Academic Publishing
Цена: 36556 тг
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Аннотация: During the early phases of a hepatitis C virus (HCV) infection, natural killer (NK) cells activation appears to be critical in the innate immune responses that have the potential of clearing the infection. Impaired activity of NK cells has been proposed as a mechanism contributing to viral persistence and chronic infection in HCV infection. We aim to assess the impact of HCV infections on NK cells regarding frequency, and subset distribution. The correlation between the phenotype of NK subsets and the various stages was assayed. Number of total NK cells was significantly reduced and a striking shift in NK subsets, with a marked decrease in the CD56-dim cell fraction compared to CD56-bright cells was identified. The number of Nk cells bearing the inhibitory receptor CD158b(KIR) increased in HCV patients at advanced stages, whereas those bearing activating receptors CD314(NKG2D), CD161 were significantly reduced as compared to normal.
Ключевые слова: Hepatitis C virus, natural killer cells
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