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Formulation and Evaluation of Sustained release tablets of Tizanidine.
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Yamsani Vamshi Vishnu,Venkata Raghava Reddy P. and Rayala Venkatakoteswararao
ISBN: 9783330051560
Год издания: 2017
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 104
Издательство: LAP LAMBERT Academic Publishing
Цена: 29611 тг
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Аннотация: The objective of this study is to formulate and evaluate the sustained release matrix tablet of Tizanidine Hydrochloride by direct compression method. In the present study, Tizanidine is chosen as a model drug which is Muscle relaxant. Because of its short half life (2.5hrs), its water solubility and less bioavailability (40%) it was chosen as a suitable candidate for sustain matrix tablet formulation. It was formulated in to matrix tablet using polymer such as iota-Carrageenan and Polyethylene oxide as releases retardants. All the pre-compression parameters, post-compression parameters were found to be within the standard IP limits. Matrix tablet with Carrageenan and Polyethylene oxide successfully sustained the release of Tizanidine for a period of 12hrs. The concentration of tizanidine was kept constant, MCC-101 and lactose (1:3 ratio) used as filler. The maximum in-vitro release (at 50rpm, temperature 37±0.5°C, and 0.1N HCl, pH 6.8 phosphate buffers) was found to be 97.8% and 98.6% over a period of 12hrs for formulations C4 and P4. The data of in-vitro release from tablets were fitted to different kinetic models to explain the release profile. Formulations C4 and P4 were best
Ключевые слова: Carrageenan, Matrix Tablet, Tizanidine HCl, Polyethylene oxide direct compression technique.
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