Formulation And Evaluation Of Sustained Release Microspheres. Development Of Microsphere

      Аннотация: Microspheres of Meclizine were prepared using the non-aqueous emulsification solvent evaporation method. The impact of different factors such type of eudragit polymer as matrix polymer. The morphology of microspheres was studied using optical and scanning electron microscopy and it was observed that microspheres had a spherical shape and smooth surface. The percentage yield of microspheres of all formulation was in the range of 82.5 % to 96.4 % . The drug content determination showed that even if the polymer composition was changed the solvent evaporation process was highly efficient to give microspheres having maximum drug loading. In conclusion, the prolonged sustained release time and enhanced stability resulting from the meclizine microspheres might make contribution to its use.

Ключевые слова: Microspheres, Meclizine HCl, Solvent Evaporation method.