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Structure Activity Relationship of Drugs of Abuse. Synthetic Cannabinoids, Synthetic Cathinones and Fentanyl analogues
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Kersty Axisa,Janis Vella Szijj and Anthony Serracino Inglott
ISBN: 9786139932672
Год издания: 2018
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 268
Издательство: LAP LAMBERT Academic Publishing
Цена: 51409 тг
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Аннотация: Structures of novel psychoactive substances are based on the structure activity relationship (SAR) of existing drugs of abuse. The study identified links between structural modifications and toxicities, adverse and physiological effects of cannabinoids, cathinones and opioids. Literature review identified the structural backbone, toxicities, adverse and physiological effects of cannabinoids, cathinones and opioids. SAR of cannabinoids, cathinones and opioids was based on amino alkylindoles, cathinone derivatives and fentanyl derivatives. Synthetic cannabinoids XLR-11 and MDMB-CHMICA have been linked to acute kidney injury due to over stimulation of CB1 receptors. The synthetic cathinones MDPV and ?-PVP cause a higher occurrence of psychosis and delirium compared to other synthetic cathinones due to inhibitory uptake effects at dopamine and norepinephrine transporters. Fentanyl analogues having a lower lipophilic value than fentanyl had a shorter duration of physiological effects compared to fentanyl analogues having higher lipophilic values than fentanyl. The study contributes to an explanation of the higher potencies, toxicities and adverse effects associated with synthetic drugs.
Ключевые слова: Structure activity relationship, Drugs of Abuse, toxicity, synthetic drugs, Adverse Drug effects, cannabinoids, Cathinones, opioids, Amino alkyl indoles, Fentanyl, analogues, NPS
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