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Synthesis of Some Novel Bioactive Indoles as Anticancer Agents. Bioactive Indoles
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| Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Sobhi Gomha,Abdou O. Abdelhamid and Sahar Kandeel
ISBN: 9786202516600
Год издания: 2020
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 116
Издательство: LAP LAMBERT Academic Publishing
Цена: 32457 тг
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Отрасли знаний:Код товара: 569349
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Аннотация: The original work consists of two projects: In the first project: 5-(Aryldiazenyl)-thiazoles and 1,3,4-thiadiazoles bearing indole were synthesized via reaction of hydrazonoyl halides and indole-thiosemicarbazone and alkyl (indolyl)carbodithioate, respectively. In the second project: 3-Acetylindole proved to be a useful precursor for the synthesis of various 1,3-thiazoles, 1,3,4-thiadiazoles and pyrido[3,2-e][1,2,4] triazolo[4,3-a]pyrimidin-5(7H)-one. Fifteen of the new compounds have been evaluated for their antitumor activity against the human breast carcinoma cell line. The results indicated that many of the tested compounds showed moderate to high anticancer activity.
Ключевые слова: 3-Acetylindole, 1, 3, 4-thiadiazoles, 3-thiazoles, pyrazoles; coupling reactions; thiosemicarbazides; hydrazonoyl halides, anti-cancer activity.
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