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Self Micro Emulsifying Drug Delivery System. Formulation & Evaluation of Supersaturable Dry Microemulsion for the Enhancement of Dissolution
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Pallavi Chede,Vishal Pande and Aishwarya Shinde
ISBN: 9786204197920
Год издания: 1905
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 80
Издательство: LAP LAMBERT Academic Publishing
Цена: 23919 тг
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Аннотация: Supersaturable SMEDDS appeared to be an interesting approach to alleviate problems associated with oral delivery of Nebivolol. This can be achieved by using NEB-SMEDDS having the formula as Castor oil (30 %,v/v), Tween-80 (35 %,v/v), PEG-400 (35 %,v/v) and HPMC(5%)was successfully optimized to achieve higher release as well as bioavailability of NEB in F8 formulation of SMEDDS in comparison to plain drug suspension. Stability of the formulation was confirmed by thermodynamic stability study and long term stability study. The release and bioavailability from F8 SMEDDS was increased due to presence of drugs in lipidic micro form as well as in dissolved state.In this book, the solid SMEDDS of NEB was prepared by adsorption method, using Aerosil-200 as adsorbent. The solid SMEDDS consisted of well-separated particles with smooth surface and preserved the self-emulsi?cation performance of the liquid SMEDDS. The DSC study shows that NEB S-SMEDDS may be in the dissolved state. In-vitro dissolution test showed that the solid SMEDDS had a faster in vitro release rate than the plain drug suspension NEB.
Ключевые слова: Self Microemulsifying drug delivery, dissolution enhancement, Solid carriers
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