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Formulation, Development & Evaluation of Multi-compartment Dosage Form. For Immediate Relief From Hypertension
В наличии
| Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Naisarg Pujara and Ramesh Parmar
ISBN: 9783659410475
Год издания: 2013
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 188
Издательство: LAP LAMBERT Academic Publishing
Цена: 46437 тг
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Аннотация: In the present study, formulation of multi-compartment dosage form containing soft gelatin capsule of Nifedipine, granules of Losartan potassium and fast disintegrating tablet of Hydrochlorothiazide was designed to achieve immediate release of drug from the dosage form, to increase therapeutic efficacy and to improve patient compliance in case of hypertension. Triple combination of antihypertensive drugs induces superior reduction in blood pressure as compared to conventional dosage form. The basic aim of this work is to produce immediate release action of drug from the hard gelatin capsule containing soft gelatin capsule of Nifedipine, granules of Losartan potassium and fast disintegrating tablet of Hydrochlorothiazide. Soft gelatin capsule was prepared by encapsulation method using propylene glycol and PEG 400 as solubilizing agents. The granules were prepared by wet granulation method using PVP K30 as binder. The fast disintegrating tablets were prepared by direct compression method using croscarmellose sodium and crospovidone as super disintegrating agents. Multi-compartment dosage form was considered as optimized formulation for immediate release of antihypertensive drugs.
Ключевые слова: Granules, Soft gelatin capsule, Multi-compartment dosage form, Innercap technology, Fast Disintegrating Tablet.
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